2026 Mercedes-Benz E 350 vs E 450

View E-Class Inventory  Compare on E-Class Hub  Schedule a Test Drive

The E 450 features a 375-horsepower engine compared to 255 horsepower in the E 350. Both executive models utilize advanced mild hybrid drive technology for exceptional efficiency and smooth acceleration. Discover your ideal level of performance by exploring our new luxury sedan inventory today.

Powertrain and Acceleration Dynamics

The defining contrast between these two exceptional luxury sedans is found in their engine configurations. The 2026 Mercedes-Benz E 350 is powered by a sophisticated 2.0-liter inline-4 turbo engine equipped with mild hybrid drive technology. This highly efficient system produces 255 horsepower and 295 lb-ft of torque, allowing the vehicle to accelerate from 0 to 60 mph in 6.1 seconds. For drivers prioritizing a quiet, refined commute across the Black Warrior River, this powertrain delivers incredibly smooth and frictionless momentum.

Buyers requiring aggressive acceleration should evaluate the 2026 Mercedes-Benz E 450 4MATIC® Sedan. This model steps up to a robust 3.0-liter inline-6 turbo engine, also featuring a mild hybrid system. Generating 375 horsepower and 369 lb-ft of torque, this larger engine drastically reduces the 0 to 60 mph time to just 4.4 seconds. This surge of immediate power translates directly into absolute confidence when merging onto fast-moving sections of Interstate 20 or passing slower traffic on rural routes.

Drivetrain Options and Shared Luxury

Beyond engine output, drivetrain availability separates these models. The E 350 offers the choice of classic rear-wheel drive or the intelligent all-wheel drive system, while the E 450 comes standard with 4MATIC® all-wheel drive. Regardless of your choice, both vehicles feature the highly responsive 9G-TRONIC 9-speed automatic transmission.

While their power profiles differ, both configurations maintain the exact standard of executive luxury expected from the brand. For a detailed exploration of the shared passenger dimensions and cabin technology, please read our comprehensive 2026 Mercedes-Benz E-Class Sedan overview. To view exact specifications directly from the manufacturer, you can visit the official Mercedes-Benz USA specification portal.

2026 Mercedes-Benz E-Class Engine Comparison

Specification2026 E 350 Sedan2026 E 450 4MATIC® Sedan
Engine Configuration2.0L Inline-4 Turbo w/ Mild Hybrid3.0L Inline-6 Turbo w/ Mild Hybrid
Horsepower255 hp375 hp
Torque295 lb-ft369 lb-ft
0-60 MPH Acceleration6.1 seconds4.4 seconds
View E-Class Inventory  Compare on E-Class Hub  Schedule a Test Drive

Base MSRP excludes transportation and handling charges, destination charges, taxes, title, registration, preparation and documentary fees, tags, labor and installation charges, insurance, and optional equipment, products, packages and accessories. Options, model availability and actual dealer price may vary. See dealer for details, costs and terms.

AMG® and 4MATIC® are registered trademarks of Mercedes-Benz Group AG.
Android Auto™ is a trademark of Google LLC.
Apple CarPlay® is a registered trademark of Apple Inc.
harman/kardon® and Logic 7 are registered marks of Harman International Industries, Incorporated
Burmester® is a registered trademark of Burmester Audiosysteme GmbH, Berlin, Germany
Bluetooth® is a registered mark of Bluetooth SIG, Inc.